Palladium-Catalyzed Decarboxylativeortho-Acylation ofO-Methyl Ketoximes via Direct sp2C—H Bond Activation
نویسندگان
چکیده
منابع مشابه
Palladium-catalyzed decarboxylative acylation of O-methyl ketoximes with a-keto acids†
Aryl ketones are important structural motifs found in natural products, medicinally relevantmolecules, and functionalmaterials. In particular, 1,2-diacylbenzenes are known to be crucial synthetic precursors to construct a wide range of biologically active compounds including phthalazines, phthalimidines, isobenzofuranes, indanones, isoindoles, and isoindolines. These facts have led to increasin...
متن کاملPalladium-catalyzed decarboxylative acylation of O-methyl ketoximes with α-keto acids.
A mild, practical and efficient palladium-catalyzed decarboxylative ortho-acylation of O-methyl ketoximes with α-keto acids via C-H bond activation is described. In these reactions, a broad range of O-methyl ketoximes and α-keto acids undergoes the decarboxylative cross-coupling reactions with high selectivities and good tolerance.
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A solvent-free palladium-catalyzed ortho-iodination of acetanilides using N-iodosuccinimide as the iodine source has been developed under ball-milling conditions. This present method avoids the use of hazardous organic solvents, high reaction temperature, and long reaction time and provides a highly efficient methodology to realize the regioselective functionalization of acetanilides in yields ...
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[Reaction: see text]. Nitrogen heterocycles are present in many compounds of enormous practical importance, ranging from pharmaceutical agents and biological probes to electroactive materials. Direct functionalization of nitrogen heterocycles through C-H bond activation constitutes a powerful means of regioselectively introducing a variety of substituents with diverse functional groups onto the...
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ژورنال
عنوان ژورنال: Acta Chimica Sinica
سال: 2013
ISSN: 0567-7351
DOI: 10.6023/a13020198